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Study Links Levothyroxine Use to Increased Osteoporosis Risk in Older Adults

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A new study reveals that levothyroxine, a common medication for hypothyroidism, may increase the risk of osteoporosis in older adults, prompting calls for careful monitoring and reassessment of treatment protocols.

The study underscores the need for careful monitoring of thyroid hormone prescriptions in older adults to prevent potential overuse.

It highlights the delicate balance between treating hypothyroidism effectively and avoiding the risks associated with excessive thyroid hormone levels.

The findings may prompt healthcare providers to reconsider treatment protocols for older patients, particularly regarding bone health.

Future research may explore alternative treatments for hypothyroidism that pose less risk to bone density.

Healthcare guidelines may evolve to include more stringent monitoring of bone health in patients prescribed levothyroxine.

Increased awareness of the risks associated with levothyroxine could lead to more personalized treatment plans for older adults.


A recent study has linked levothyroxine, a commonly prescribed medication for hypothyroidism, to an increased risk of osteoporosis in older adults. Levothyroxine is the second most prescribed drug among this demographic in the United States. While it is essential for treating hypothyroidism, which can lead to serious health issues if left untreated, excessive use can lead to hyperthyroidism, causing various health complications including heart issues and increased fracture risk.

The research, led by Dr. Shadpour Demehri from Johns Hopkins University, indicates that even when prescribed according to current guidelines, levothyroxine may contribute to greater bone loss in older patients. Co-author Dr. Elena Ghotbi highlighted concerns over the potential overprescription of thyroid hormones to older adults who may not actually have hypothyroidism.

The study utilized data from the Baltimore Longitudinal Study of Aging, focusing on participants over 65 years old. Among the 445 participants, those taking levothyroxine were found to lose more bone mass over an average of six years compared to those not on the medication. This raises significant concerns about the long-term effects of levothyroxine on bone health, particularly in older populations who are already at risk for osteoporosis.

Experts recommend that individuals taking levothyroxine should engage in regular discussions with their healthcare providers to monitor thyroid function and assess the necessity of ongoing treatment. Dr. Jennifer Mammen, another co-author of the study, reassured that those properly using levothyroxine for legitimate hypothyroidism should not panic but should remain vigilant about their bone health.

  • The study's findings will be presented at the upcoming annual meeting of the Radiological Society of North America, highlighting the importance of ongoing research into the long-term effects of common medications on aging populations.
Clam Reports
Refs: | Aljazeera |

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