Russian Scientists Innovate Drug Delivery for Kidney Diseases
In a groundbreaking development, researchers from the Skolkovo Institute of Science and Technology, Saratov State University, and the National Research Mordovian State University have created a novel microgel for the targeted delivery of medications specifically to the kidneys. This advancement aims to enhance treatment efficacy while minimizing potential side effects associated with systemic drug administration. The findings were recently published in the journal Optical Materials and were supported by a grant from the Russian Science Foundation (RSF).
The innovative microgel is composed of whey protein and flaxseed oil, forming emulsion microparticles with a protein shell that encapsulates the therapeutic agent. This formulation is designed to transport drugs directly to the kidneys, significantly reducing the risk of affecting other organs. Additionally, a non-toxic fluorescent dye is incorporated into the microgel to facilitate tracking its distribution and accumulation in the tissues of experimental animals.
Prior to animal trials, the researchers conducted toxicity assessments on human embryonic kidney cells, stem cells, immune cells, and connective tissue cells. The results indicated that the microgel is non-toxic, even at high concentrations, confirming its safety for potential therapeutic applications.
During the animal studies, laboratory mice were divided into three groups. Two groups received the microgel via different administration routes—intravenously and intra-arterially—while the third group served as a control. Remarkably, the microgel was observed to reach the kidneys within five minutes of administration, subsequently accumulating there and being broken down by enzymes within a day.
Olga Sindeeva, a senior researcher at the Skolkovo Institute, emphasized the significance of this delivery system, stating, “The proposed delivery system accumulates in the kidneys, which will prevent drugs from getting into other organs. It is non-toxic due to its natural components, and our experiments have shown that microgels can be administered intravenously, providing a fast and precise method for patients.” The researchers plan to further explore the use of drug-loaded microgels for treating various kidney diseases, including those of infectious, immunological, and oncological nature.
