The University of Maryland School of Medicine has conducted a groundbreaking study that sheds light on chronic itching, a condition that afflicts millions worldwide without a known cause or approved treatment. The research, published in Scientific Reports, reveals significant deficiencies in metabolic indicators, particularly amino acids, in patients suffering from chronic idiopathic itch compared to healthy individuals. This discovery opens new avenues for understanding the underlying mechanisms of this painful condition and potentially identifying future therapeutic targets.
Lead researcher Professor Sean Kwatra emphasizes the importance of these findings, noting that the lack of certain metabolites in the blood may contribute to the severity of itching experienced by patients. Chronic itching, which persists for over six weeks, is especially prevalent among the elderly and severely impacts their quality of life. Current treatments are often ineffective and used off-label, highlighting the urgency for more effective solutions.
Additionally, previous studies on mice have shown a correlation between low amino acid levels and increased itching symptoms, suggesting a potential link between neurotransmitter regulation and the itch response. The study's findings indicate that these amino acids not only influence neurotransmitter levels but also play a role in immune function, further complicating the pathogenesis of chronic itching. Professor Kwatra calls for larger studies to delve deeper into these metabolic markers and their implications for treatment.
